OWLS Sensors - Label free biosensors



The very first applications of the OWLS system were in the field of investigating the properties of bilayer lipid membrane and other thin films. The grating coupler sensor has enabled studies of this type to be undertaken much more conveniently than heretofore. Accessible properties include the thickness, density and anisotropy of thin films, and their changes following a perturbation can be followed in real time.

Related publications

  • Bearinger J P, Vörös J, Spencer N D, Hubbel J A, Textor M, “Nanoscale Bio- Molecular Control Using EC-OWLS, NSTI Natonech -The Nanotechnology Conference and Trade Show,Santa Clara, May 20-24, 2007
  • Tang C S, Antoni M, Schönbachler I, Keller B, Textor M, Vörös J, “Electrically- Assisted Formation and Desorption of Dodecyl Phosphate Selfassembled Monolayers on Indium Tin Oxide (ITO) Surfaces”, ECS Transactions,1(28) 29-43, 2006
  • Mhamdi L, Picart C, Lagneau C, Othmane A, Grosgogeat B, Jeffrezic-Renault N, Ponsonnet L, “Study of the polyelectrolyte multilayer thin films’ properties and correlation with the behavior of the human gingival fibroblast” Materials Science & Engineering C-Biomimetic and Supramolecular Systems, 26 (2-3): 273-281 Sp. Iss. SI Mar 2006
  • Ball V, Michel M, Boulmedais F, Hemmerle J, Haikel Y, Schaf P, Voegel JC, “Nucleation kinetics of calcium phosphates on polyelectrolyte multilayers displaying internal secondary structure “, Crystal Growth & Design, 6 (1): 327-334, Jan 2006
  • Stadler B, Falconnet D, Pfeiffer I, Hook F, Voros J, “Micropatterning of DNA-tagged vesicles”, Langmuir 20 (26): 11348-11354, Dec 21 2004
  • Voros J, “The Density and Refractive Index of Adsorbing Protein Layers”, Biophysical Journal, Volume 87, July 2004, 553-561
  • Richert L, Arntz Y, Schaaf P, Voegel JC, Picart C, “pH dependent growth of poly(Llysine)/ poly(L-glutamic) acid multilayer films and their cell adhesion properties”, Surface Science, 570 (1-2): 13-19, Oct 10 2004
  • Horváth R, Fricsovszky G, Papp E, “Application of the optical waveguide lightmode spectroscopy to monitor lipid bilayer phase transition”, Biosensors and Bioelectronics, Volume 18, Issue 4, 415-428, April 2003
  • Gergely C, Bar Yosef P, Govrin-Lippman R, Cuisinier F, Furedi.Milhofer H “The deposition of calcium phosphates within polyelectrolyte multilayer films” Bioceramics 15, 240-2: 287-290, 2003
  • Horvath R, Kerekgyarto T, Csucs G, Gaspar S, Illyes P, Ronto G, Papp E, “The effect of UV irradiation on uracil thin layer measured by optical waveguide lightmode spectroscopy.” Biosensors & Bioelectronics, 16:17. 2001
  • Ramsden J J, “Molecular orientation in lipid bilayers.” Phil. Mag. B 79) 381-386, 1999
  • Csucs G, Ramsden J J, “Interaction of phospholipid vesicles with smooth metal-oxide surfaces.” Biochimica Et Biophysica Acta-Biomembranes, 1369:61-70, 1998
  • Csucs G, Ramsden J J, “Solubilization of planar bilayers with detergent.” Biochimica Et Biophysica Acta-Biomembranes 1369:304-308, 1998
  • Máté M, Ramsden J J, “Colloidal particles efficiently scavenge fatty acid Langmuir- Blodgett films”, J. Dispersion Science and Technology 19, 875-883 1998
  • Meier W, Ramsden J J, “Surface pressure determines the interaction between poly(oxyethylene) and a surfactant bilayer”, J. Phys. Chem. 100, 1435 -1438 1996
  • Knobloch H, Woigk S, Brehmer L, Yusupov R, Rakhnyanskaya A, ” Metal ion adsorption to Langmuir-Blodgett films monitored by the optical waveguide technique”, Thin Solid Films 265, 89 – 91, 1995
  • Ramsden J J, Lvov Y M, Decher G, “Determination of optical constants of molecular films assembled via alternate polyion adsorption”, Thin Solid Films 254, 246 -251 and 261, 343 – 344, 1995
  • Ramsden J J, “Partial molar volume of solutes in bilayer lipid membranes”, Journal of Physical Chemistry 97, 4479 – 4483, 1993

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