AMGEN researchers published their first results using OWLS 210 for studying Poloxamer/ Polysorbate adsorption. Their resarch was published in April 2014 in the Journal of Pharmaceutical Sciences. Publication: Modulation of Protein Adsorption by Poloxamer 188 in Relation to Polysorbates 80 and 20 at Solid Surfaces HYOJIN L. KIM, ARNOLD MCAULEY, BRYNN LIVESAY, WARREN D. GRAY, […]
OWLS Biosensors in Pharmaceutical Research Read More »
Abstract Light-gated ion channels allow modifying transmembrane ion fluxes and consequently,the intracellular distribution of ions without applying electric fields or introducing stimulating electrodes. Channelrhodopsyn is a Na+ and Ca2+ permeable cation channel, which opens in response to illumination at wavelengths of 460-490 nm. The influx of Na+ and Ca2+ depolarizes the cells and results in
Detecting Cell Physiological Changes in Response to Light Induced Ion Channel Opening Read More »
Abstract Polymeric flagellin consists of four linearly connected domains labeled D0, D1, D2, and D3, which are arranged from the inside to the outside of the filament. The disordered terminal regions are involved in D0 and partly in D1, forming long helical bundles, and their direct interaction is responsible for stabilizing the filament structure.A central
Optical Anisotropy of Flagellin Layers Read More »
Abstract Aflatoxins are toxic metabolites produced by Aspergillus species (mainly A. Flavus, A. parasiticus,and A. nomius) and can be present in a wide range of food and feed commodities. Because of thepersistence of Aflatoxins in the food chain, exposure to the compound is a potential human healthhazard. This has prompted adoption of regulatory limits in
Label-free immunosensor for Aflatoxin B1 Read More »
Abstract Acting as a potent microtubule inhibitor, the dinitroaniline herbicide trifluralin has been used in agricultural applications as a selective, pre-emergence herbicide in various plant cultures including grain, crops, vegetables, fruits and nuts. In recent years, the compound is a subject to increasing toxicological and environmental concerns. OWLS offered a highly sensitive label free method
Label-free immunosensor for herbicide trifluralin detection with OWLS Read More »
Abstract OWLS immunosensor offers a real time label-free detection of heat shock protein, HSP70 (molecular weight of70 kDA). For biosensing monoclonal antibodies raised against HSP70 protein under investigation were used. Toform regenerable sensor surface, the waveguide sensor surface was modified with amino group and sensitized byimmobilizing antibody/antigen molecules covalently to the surface. Label-free immunosensor for
Label-free immunosensor for HSP70 detection Read More »
Abstract Immunosensors were constructed for rapid and label-free determination of TNFα concentrations in human serum samples Download the full application note
Determination of TNFa concentration in human serum Read More »
In the case of glass type metal oxide surfaces suchas SiO2-TiO2, mainly hydroxyl groups are present, which offer relatively few possibilities for covalent immobilization of biomolecules. To widen the circle of covalent coupling methods, the surface of the waveguide has to be modified by silanization using reactive silane reagents for introducing functionalgroups of all sorts
Test measurement of label-free immunosensor using BSA-antiBSA model molecule pair (GA) Read More »
