OWLS Sensors - Label free biosensors

Molecular self-assembly

Molecular self-assembly and nanoscience

Although the vast bulk of reported work involves biological molecules, the use of the OWLS grating coupler sensor is by no means confined to them. Due to the high precision with which an assembly process can be followed, the OWLS grating coupler sensor became an essential tool for investigating the fundamentals of self-assembly.

Related publications

  • Ngankam A P, Van Tassel P R, “Continuous polyelectrolyte adsorption under an applied electric potential”, PNAS | January 23, vol. 104, no. 4, 1140-1145, 2007
  • Kroslak M, “Investigation of Deposition and Adsorption on Solid-Liquid Interfaces through Optical Waveguide Lightmode Spectroscopy”, Doctoral Thesis ETH No.16580, Zurich 2006
  • Pelsoczi I, Turzo K, Gergely C, Fazekas A, Dekany I, Cuisinier F, “Structural characterization of self-assembled polypeptide films on titanium and glass surfaces by atomic force microscopy” Biomacromolecules, 6 (6): 3345-3350, Nov-Dec 2005
  • Lee S, Iten R, Muller M, Spencer ND, “Influence of molecular architecture on the adsorption of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) on PDMS surfaces and implications for aqueous lubrication” Macromolecules, 37(22): 8349-8356 Nov2 2004
  • Picart C, Gergely Cs, Arntz Y, Voegel J, Schaaf P, Cuisinier FJG, Senger B, “Measurement of film thickness up to several hundreds of nanometers using optical waveguide lightmode spectroscopy”, Biosensors and Bioelectronics, 20 (3): 553-561, Oct 15 2004
  • Kiss É, Erdelyi K, Szendro I, Vargha-Butler EI, “Adsorption and Wetting Properties of Pluronic Block Copolymers on Hydrophobic Surfaces Studied by optical Waveguide Lightmode Spectroscopy and Dynamic Tensiometric Method”, Journal of Adhesion, 80:815-829, Sept 2004
  • Picart C, Sengupta K, Schilling J, Maurstad G, Ladam G, Bausch AR, Sackman E, “Microinterferometric study of the structure, interfacial potebtial, and viscoelastic properties of polyelectrolyte multilayer films on a planar substrate” Journal of Physical Chemistry B, 108 (22): 7196-7205, Jun 2004
  • Gergely C, Bar Yosef P, Govrin-Lippman R, Cuisinier F, Furedi.Milhofer H “The deposition of calcium phosphates within polyelectrolyte multilayer films”, Bioceramics 15, 240-2: 287-290, 2003
  • Boulmedais F, Ball V, Schwinte P, Frisch B, Schaaf P, Voegel JC “Buildup of exponentially growing multilayer polypeptide films with internal secondary structure” Langmuir 19 (2): 440-445, Jan 2003
  • Picart C, Mutterer L, Richert L, Luo Y, Prestwich GD, Schaaf P, Voegel JC, Lavalle P “Molecular basis for the explanation of the exponential growth of polyelectrolyte multilayers”, PNAS USA, 99 (20): 12531-12535, Oct 2002 11. Sefcik J, Kroslak M, Morbidelli M, “Optical response of porous titania-silica waveguides to surface charging in electrolyte filled pores” Helvetica Chimica Acta, 85 (10): 3508-3515 2002
  • Lavalle P, Gergely C, Cuisinier FJG, Decher G, Schaaf P, Voegel JC, Picart C “Comparison of the structure of polyelectrolyte multilayer films exhibiting a linear and an exponential growth regime: An in situ atomic force microscopy study” Macromolecules, 35 (11): 4458-4465, May 2002
  • Horvath R, Voros J, Graf R, Fricsovszky G, Textor M, Lindvold L R, Spencer N D, Papp E, “Effect of patterns and inhomogeneities on the surface of waveguides used for optical waveguide lightmode spectroscopy applications” , Applied Physics B: Lasers and Optics 2001. 72:441.
  • Mann E K , “Evaluating optical techniques for determining film structure: Optical invariants for anisotropic dielectric thin films”, Langmuir 17:5872-5881, 2001
  • Picart C, Ladam G, Senger B, Voegel J C, Schaaf P, Cuisinier F J G, Gergely C, “Determination of structural parameters characterizing thin films by optical methods: A comparison between scanning angle reflectometry and optical waveguide lightmode spectroscopy”, Journal of Chemical Physics 115:1086-1094, 2001
  • Guemouri, L., Ogier J., Zekhnini Z., and Ramsden J. J., “Architecture of fibronectin at surfaces.” Journal of Chemical Physics, 113:8183, 2000
  • Brovelli D, Hahner G, Ruiz L, Hofer R, Kraus G, Waldner A, Schlosser J, Oroszlan P, Ehrat M, Spencer N D, “Highly oriented, self-assembled alkanephosphate monolayers on tantalum(V) oxide surfaces.” Langmuir 15:4324. 1999
  • Mate M, Ramsden J J , “Addition of particles of alternating charge.” J. Chem. Soc. Faraday Trans. 94:2813. 1998
  • Csucs G, Ramsden J J , “Generalized ballistic deposition of small buoyant particles.” J. Chem. Phys. 109:779. 1998
  • Guemouri L, Ogier J, Ramsden J J, “Optical properties of protein monolayers during assembly.” Journal of Chemical Physics 109:3265-3268. 1998
  • Ramsden J J, Máté M, “Kinetics of monolayer particle deposition”, J. Chem. Soc. Faraday Trans. 94(6), 783-788, 1998
  • Máté M, Ramsden J J, “Addition of particles of alternating charge”, J. Chem. Soc. Faraday Trans. 94, 2813-2816, 1998
  • Ball V, Ramsden J J , “Absence of Surface Exclusion in the First Stage of Lysozyme Adsorption Is Driven through Electrostatic Self-Assembly.” J. Phys. Chem. B 101:5465. 1997
  • Constable E C, Haverson P, Ramsden J J, “Adsorption of ruthenadendrimers to silicatitania surfaces studied by optical waveguide lightmode spectroscopy (OWLS)” Chem. Commun., 1683-1684, 1997

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