OWLS Sensors - Label free biosensors

Protein DNA-RNA interactions

Overview

Since the grating coupler sensor can be easily coated with very long DNA molecules, it is ideally suited to investigate both hybridization and protein binding.

Related publications

  • Stadler B, Falconnet D, Pfeiffer I, Hook F, Voros J, “Micropatterning of DNA-tagged vesicles”, Langmuir 20 (26): 11348-11354, Dec 21 2004
  • De Paul S M, Pasche S, Textor M, Spencer N D, Kauffmann E, Abel A, Ehrat M, “Controlled Biosensor Surfaces for Optical DNA/RNA Sensors” The 7th Word Congress on Biosensors Kyoto Japan 15-17 May 2002
  • Chiu M L, Viollier P H, Katoh T, Ramsden J J, Thompson C J, “Ligand-induced changes in the Streptomyces lividans TipAL protein imply an alternative mechanism of transcriptional activation for MerR-like proteins.” Biochemistry;40(43):12950-8, Oct 30 2001
  • Kleinjung F, Klussmann S, Erdmann V A, Scheller F W, Fürste J P, Bier F F, “High affinity RNA as recognition element in a biosensor”, Analytical Chemistry 70 (1998), 328-331
  • Bier F F, Fürste J P, “Nucleic acid based sensors” in Frontiers in Biosensorics, Eds. F. W. Scheller, F. Schubert und J. Fedrowitz, Birkhauser, Basel, 1997, 97-120
  • Bier F F, Kleinjung F, Scheller F W, “Real time measurement of nucleic acid hybridization using evanescent wave sensors -steps towords the genosensor, Sensors and Actuators B38-39 (1997), 78-82
  • Börchers T, Spener F, Sprecht B, Kruchinin A A, Vlasov Y G, “Peculiarities of recognition element for DNA biosensor”, Preceedings of the 11th European Conference on Solid State Transducers, Eurosensors XI, 1997, Warsaw, Poland, 1437-1440
  • Börchers T, Spener F, Kruchinin A A, Vlasov Y G, “Biosensor for DNA detection on the basis of integrated optical waveguide”, Preceedings of the 11th European Conference on Solid State Transducers, Eurosensors XI, 1997, Warsaw, Poland, 1433-1436
  • Kleinjung F, Bier F F, Warsinke A, Scheller F W, “Fibreoptic genosensor for specific determination of femtomolar DNA oligomers”, Analytica Chemica Acta 350 (1997), 5159 10. Ramsden J J, Dreier J, “Kinetics of the interaction between DNA and the type IC restriction enzyme EcoR124II -Biochemistry, 35 (12), 3746 -3753, 1996
  • Bier F F, Scheller F W, “Label-free observation of DNA-hybridisation and endonuclease activity on a waveguide surface using a grating coupler”, Biosensors & Bioelectronics 11 (1996), 669-674

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