The only real-time, label-free biosensor device that combines QCM with dissipation, OWLS and EC (electrochemical) measurements in a single, integrated platform:
The QCM measuring unit is a high sensitivity mass sensor which measures the change in frequency of a quartz crystal resonator and as a label free biosensor it measures the “wet mass” of the adsorbed layer in processes occurring at or near the sensor surface. The measuring principle is based on impedance analysis of the quartz crystal. The resonant frequency and the bandwidth of the resonant conductance curve are determined. The bandwidth or full width at half maximum, ( FWHM ) is direct correlation with the quality factor ( Q ) which is by definition the inverse of the well known dissipation ( D )
The OWLS measuring unit is a high sensitivity (~1ng/cm2 ), real-time, label free optical biosensor system, which measures the “dry mass” of the adsorbed layer. Chemical and bio-chemical interactions can be followed and quantified in real time, thus revealing the specificity, the dynamics and the strength of the reaction and/or the binding. Temperature control included.